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M94A2427.TXT
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Document 2427
DOCN M94A2427
TI Correlation between timing of rupture of amniotic membranes and risk of
HIV-1 perinatal transmission.
DT 9412
AU Paiva JV; Hutto C; Antunes C; Scott G; Federal University of Minas
Gerais, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):307 (abstract no. PC0159). Unique
Identifier : AIDSLINE ICA10/94370148
AB OBJECTIVES: To study the association between duration of rupture of
amniotic membranes (ROM) and risk of perinatal HIV-1 transmission in a
group of HIV-1 infected mothers. METHODS: A retrospective review of the
maternal medical records of 132 HIV-1 infected mothers who along with
their infants were enrolled in a prospective study of perinatal HIV-1
transmission was done to obtain labor and delivery data. All of the
mothers were born in Haiti and delivered at a single metropolitan
hospital in south Florida between 1986 to 1989 and all denied drug use
and blood transfusions. The rate of perinatal infection was compared for
mothers whose rupture of membranes prior the delivery was > 12 hours and
< 12 hours. RESULTS: 103 (78%) of 132 were delivered by vaginal
delivery. Thirty-six of 132 (27%) children were infected and, of these,
11 (30.6%) were delivered vaginally. The trend analysis found that the
risk of transmission was greater for infants born to mothers whose ROM
was > 12 hours than for those < 12 hours (OR = 3, x2 = 4.6, p = 0.03).
For women delivering vaginally, the correlation was greater than for
women who were delivered by C-section. Other factors e.g. maternal age,
maternal lymphocytes count, scalp electrode use, episiotomy, type of
delivery that may be associated with transmission were also evaluated.
CONCLUSION: These data suggest that prolonged rupture of membranes in
HIV-1 infected women delivering vaginally is a risk factor for perinatal
transmission of virus. The increased risk is presumable due to the
infant's exposure to maternal cervical and vaginal secretion and blood
during labor and delivery.
DE Delivery Female Fetal Membranes, Premature Rupture/*COMPLICATIONS
Human HIV Infections/*TRANSMISSION *HIV-1 Infant, Newborn Pregnancy
*Pregnancy Complications, Infectious Prospective Studies Retrospective
Studies Risk Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).